Accelerated biological aging mediates the associations of stress hyperglycemia ratio (SHR) with mortality in type 2 diabetes and obesity (diabesity).

Jinling Xu, Hui Zhou, Zhongjing Wang

Department of Endocrinology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, Hubei, China. · pubmed

Paper

Abstract

Stress hyperglycemia ratio (SHR) has emerged as an innovative biomarker for stress-induced hyperglycemia and various disease prognosis, yet its relationship with mortality in patients with type 2 diabetes and obesity (termed as diabesity) remains unclear. Accelerated biological aging increases susceptibility to chronic diseases and death. This study sought to examine the association between SHR and mortality in type 2 diabetes and obesity, and also investigate the potential mediating effects of accelerated biological aging in this relationship.

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Research summary

The paper claims that accelerated biological aging mediates the relationship between stress hyperglycemia ratio and mortality in type 2 diabetes and obesity. This research is relevant as it explores the connection between biological aging and mortality, addressing a potential root cause of age-related diseases rather than merely treating symptoms.

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