Sex differences in the association between visceral adiposity index and biological aging: A cross-sectional analysis of NHANES 1999-2018 with mediation by insulin resistance.

Jia Yang, Haifeng Liu, Xupeng Huang, Zimin Fu, Jie Zhou, Tiejun Liu, Weimin Zhao

College of Chinese Medicine, Changchun University of Chinese Medicine, Changchun City, Jilin Province, China.College of Chinese Medicine, Changchun University of Chinese Medicine, Changchun City, Jilin Province, China. · pubmed

Paper

Abstract

Aging poses challenges global health and social care systems, with obesity potentially being associated with this process. However, sex differences and the mediating mechanisms underlying this association remain poorly understood. This study investigated sex differences in the associations of visceral adiposity index (VAI) with biological aging (BA) assessed via the Klemera-Doubal method age (KDMAge) and the risk of KDMAge acceleration (KDMAgeAccel), and explored the mediating role of the homeostasis model assessment of insulin resistance (HOMA-IR).

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that sex differences influence the relationship between visceral adiposity index and biological aging, mediated by insulin resistance. This research addresses the underlying mechanisms of aging and obesity, contributing to the understanding of biological aging processes.

Author of this paper? Send a correction.