Active aging activities and genetic determinants of cognitive health: findings from the Kuakini Honolulu-Asia Aging Study.

Yeonjung J Lee, Kamal H Masaki, Randi Chen, Peter Martin, Ernest Gonzales, Cliff Whetung, Katsumi Takemoto, Bradley J Willcox

Department of Social Work, Thompson School of Social Work & Public, Health University of Hawai'i at Mānoa, Honolulu, Hawaii, United States.Department of Social Work, Thompson School of Social Work & Public, Health University of Hawai'i at Mānoa, Honolulu, Hawaii, United States. · pubmed

Paper

Abstract

The role of an active lifestyle and genetic factors in promoting cognitive health is critical. However, few have simultaneously considered both lifestyle and genetic influences to assess how these factors are associated with cognitive health. Informed by the productive aging framework and the cognitive reserve theory, the present study investigates productive and leisure activities, apolipoprotein E epsilon 4 (APOE-ε4), and Forkhead box O3 (FOXO3) genotypes, with cognitive health among older Japanese-American men.

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Research summary

The study claims that both active lifestyle choices and specific genetic factors are associated with cognitive health in older adults. This paper is relevant as it explores the interplay between lifestyle and genetic determinants in cognitive health, which is crucial for understanding factors that may contribute to healthy aging and longevity.

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