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RESEARCH PAPER / 2025-09-26

Enhancing Late-Life Survival and Mobility via Mitohormesis by Reducing Mitochondrial Calcium Levels.

Doruntina Bresilla, Ines Tawfik, Martin Hirtl, Sonja Gabrijelčič, Julian Ostaku, Fabienne Mossegger, Lia Wurzer, Susanne Lederer, Katarina Kalinova, Ernst Malle, Markus Schosserer, Kim Zarse, Michael Ristow, Corina T Madreiter-Sokolowski

Division of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria. · pubmed

Abstract

Mitochondrial calcium (Ca

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Research summary

The paper claims that reducing mitochondrial calcium levels can enhance late-life survival and mobility through mitohormesis. This research addresses a potential mechanism underlying aging and longevity, focusing on mitochondrial function, which is a critical aspect of age-related decline.

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