Phosphorylation-mimicking histone H3.3 rescues exercise-induced gene responses in an epigenetic aging model of mouse skeletal muscle.
Abstract
With aging, the canonical histone H3.1/3.2 in skeletal muscle is progressively replaced by the non-canonical variant H3.3. Although H3.3 is thought to be involved in age-related epigenetic regulation due to its role as a histone variant, its functional characteristics remain largely unknown. Serine 31 (S31) is a unique amino acid residue of H3.3 that undergoes phosphorylation. Therefore, the present study aimed to investigate the relationship between skeletal muscle aging and H3.3 phosphorylation at S31 (H3.3S31ph).
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Research summary
The study investigates the role of phosphorylation of histone H3.3 in skeletal muscle aging and its potential to influence gene responses related to exercise. This research addresses a mechanism related to epigenetic regulation in aging, which is pertinent to understanding the biological processes of aging and potential interventions.
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