Retinal polyunsaturated fatty acid supplementation reverses aging-related vision decline in mice.

Fangyuan Gao, Emily Tom, Cezary Rydz, William Cho, Alexander V Kolesnikov, Yutong Sha, Anastasios Papadam, Samantha Jafari, Andrew Joseph, Ava Ahanchi, Nika Balalaei Someh Saraei, David C Lyon, Andrzej Foik, Qing Nie, Felix Grassmann, Vladimir J Kefalov, Dorota Skowronska-Krawczyk

Gavin Herbert Eye Institute - Robert M. Brunson Center for Translational Vision Research, Department of Ophthalmology and Vision Sciences, University of California, Irvine, CA 92697, USA.Gavin Herbert Eye Institute - Robert M. Brunson Center for Translational Vision Research, Department of Ophthalmology and Vision Sciences, University of California, Irvine, CA 92697, USA. · pubmed

Paper

Abstract

The retina is uniquely enriched in polyunsaturated fatty acids (PUFAs), primarily localized in cell membranes, where they govern membrane biophysical properties. During aging, alterations in lipid metabolism lead to reduced content of very long-chain PUFAs (VLC-PUFAs) in the retina, which is associated with normal age-related reductions in contrast sensitivity, diminished photoreceptor function and delayed rod-mediated dark adaptation recovery, and pathological age-related macular degeneration (AMD).

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Research summary

Supplementation with retinal polyunsaturated fatty acids can reverse aging-related vision decline in mice. The paper addresses the impact of lipid metabolism on age-related vision decline, which is a fundamental aspect of aging and its effects on sensory functions.

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