Integrated mRNA-seq and miRNA-seq analysis reveals miR-210a-5p regulates uterine aging in laying hens by targeting the RASL11B/Raf/MAPK pathway.

Xiyu Zhao, Xinyan Li, Wenxin Zhang, Mingyue Gao, Conghao Zhong, Boxuan Zhang, Congjiao Sun, Yao Zhang, Shunshun Han, Huadong Yin

State Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Agricultural Bioinformatics, Ministry of Education, Key Laboratory of Livestock and Poultry Multi-Omics, Ministry of Agriculture and Rural Affairs, and, Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology , Sichuan Agricultural University, 611130, Sichuan, People's Republic of China.State Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Agricultural Bioinformatics, Ministry of Education, Key Laboratory of Livestock and Poultry Multi-Omics, Ministry of Agriculture and Rural Affairs, and, Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology , Sichuan Agricultural University, 611130, Sichuan, People's Republic of China. · pubmed

Paper

Abstract

Uterine aging is a key factor contributing to the deterioration of egg quality and reproductive performance in laying hens. Despite its importance, the molecular mechanisms underlying uterine aging remain poorly defined. This study aimed to characterize gene expression and regulatory changes associated with uterine aging in hens at different life stages.

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Research summary

The paper claims that miR-210a-5p regulates uterine aging in laying hens by targeting the RASL11B/Raf/MAPK pathway. This research addresses molecular mechanisms of aging in a specific biological context, contributing to the understanding of aging processes.

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