Gut microbiota dynamics in SAMP8 mice: insights from machine learning and longitudinal analysis.

Yilang Ke, Aiping Zeng, Dang Li

Fujian Key Laboratory of Vascular Aging, Department of Geriatrics, Fujian Institute of Geriatrics, Fujian Clinical Research Center for Senile Vascular Aging and Brain Aging, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.Fujian Key Laboratory of Vascular Aging, Department of Geriatrics, Fujian Institute of Geriatrics, Fujian Clinical Research Center for Senile Vascular Aging and Brain Aging, Fujian Medical University Union Hospital, Fuzhou, Fujian, China. · pubmed

Paper

Abstract

The gut microbiota plays a crucial role in maintaining host health, and its composition is significantly influenced by aging. The SAMP8 mouse model, known for its accelerated aging process, is widely used to study age-related changes. However, comprehensive longitudinal studies on gut microbiota dynamics in SAMP8 mice remain limited. We analyzed microbiota profiles of SAMP8 mice at 1, 3, 7, and 10 months (

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Research summary

The paper investigates the dynamics of gut microbiota in SAMP8 mice across different ages. This research is relevant as it explores the relationship between gut microbiota and aging, potentially addressing underlying mechanisms of age-related changes.

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