Investigating causal effects of HDL-C on cognitive function through cross-sectional and Mendelian randomization analyses: concentration-response patterns and clues for Alzheimer's disease prevention.

Longmin Fan, Haitao Jiang, Zheyu Zhang

Department of Integrated Traditional Chinese & Western Medicine, The Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Road, Changsha, Hunan, 410011, China.Department of Integrated Traditional Chinese & Western Medicine, The Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Road, Changsha, Hunan, 410011, China. · pubmed

Paper

Abstract

Disrupted cholesterol homeostasis may accelerate cognitive aging. This study investigated the relationship between serum HDL-C levels and cognitive function, utilizing cross-sectional data and Mendelian randomization (MR) analysis.

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Research summary

The paper claims that serum HDL-C levels have a causal relationship with cognitive function and may provide insights for Alzheimer's disease prevention. The study addresses cholesterol homeostasis and its potential role in cognitive aging, which is relevant to understanding mechanisms that could influence longevity and age-related cognitive decline.

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