Effects of apelin on age-associated neovascularization impairment in peripheral artery disease.

Junyu Chen, Minghong Chen, Yu Liu, Xuerui Wang, Meilian Yao, Jing Chen, Jian Zhang, Qunyong Peng

Department of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.Department of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China. · pubmed

Paper

Abstract

Peripheral artery disease (PAD) is a prevalent vascular condition in the elderly. Aging induces senescence and dysfunction of endothelial cells (ECs), which contributes to impaired neovascularization. This study aims to investigate the therapeutic potential of apelin in restoring neovascularization in older patients with PAD.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that apelin can restore neovascularization in older patients with peripheral artery disease. This research addresses a specific aspect of age-related vascular dysfunction, which is relevant to understanding and potentially mitigating the effects of aging on vascular health.

Author of this paper? Send a correction.