Intrinsic Capacity Defined Using 4 Domains, Genetic Risk, and Incident Parkinson Disease: A Prospective Cohort Study.

Wei Hu, Ge Tian, Jia-Ning Wang, Yu-Bin Ma, Zi-Ang Zheng, Tong-Jie Feng, Xiao-Xin Niu, Yi-Ning Yan, Bao-Peng Liu, Cun-Xian Jia

From the Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.From the Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China. · pubmed

Paper

Abstract

Intrinsic capacity (IC), a World Health Organization-defined measure of healthy aging, has been linked to several neurologic disorders but has not been extrapolated to Parkinson disease (PD). The study aimed to explore the association between IC and incident PD and whether genetic risk modulated this association.

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Research summary

The study investigates the association between intrinsic capacity and the incidence of Parkinson disease, considering genetic risk factors. This research is relevant as it explores a potential link between a measure of healthy aging and a specific age-related neurodegenerative disease, contributing to the understanding of aging processes.

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