Colla Corii Asini regulate collagen regeneration in UV exposure-induced skin photoaging in mice.

Yuman Ma, Jun Huang, Junxiao Gong, Lishuang Li, Yujia Zhao, Yucui Jin, Jianjun Gu, Haibin Liu, Yi Wang, Yanan Sun

Experimental Research Center, China Academy of Chinese Medical Sciences, No.16, Nanxiao Street, Dongzhimen, Dongcheng District, Beijing, People's Republic of China.Experimental Research Center, China Academy of Chinese Medical Sciences, No.16, Nanxiao Street, Dongzhimen, Dongcheng District, Beijing, People's Republic of China. · pubmed

Paper

Abstract

Ultraviolet (UV) radiation is the primary external factor driving skin aging, mainly due to imbalanced collagen synthesis and degradation. Identifying new drugs targeting collagen regeneration may effectively delay skin aging. Colla Corii Asini (CCA), derived from donkey skin, contains abundant proteins and peptides, suggesting potential benefits against photoaging through collagen homeostasis regulation. However, its mechanisms and active components remain unclear.

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Research summary

Colla Corii Asini may enhance collagen regeneration to mitigate skin photoaging. The study addresses a mechanism related to collagen homeostasis, which is a fundamental aspect of skin aging and longevity.

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