Hierarchical ROS-scavenging platform breaks vicious cycle of stem cell senescence, angiogenesis arrest, and immune dysregulation in diabetic wounds.

Shuo Wang, Jiaheng Liang, Rui Ding, Weihao Zhao, Jianhong Zhang, Pandi Peng, Jin Chai, Yibo Yan, Peng Li

State Key Laboratory of Flexible Electronics (LoFE), Institute of Flexible Electronics (IFE), Shaanxi Key Laboratory of Flexible Electronics, Ningbo Institute, Northwestern Polytechnical University (NPU), Xi'an 710072, China.State Key Laboratory of Flexible Electronics (LoFE), Institute of Flexible Electronics (IFE), Shaanxi Key Laboratory of Flexible Electronics, Ningbo Institute, Northwestern Polytechnical University (NPU), Xi'an 710072, China. · pubmed

Paper

Abstract

Diabetic chronic wounds represent a formidable clinical challenge, driven by a pathological vicious cycle of reactive oxygen species (ROS)-induced oxidative stress, stem cell senescence, angiogenesis arrest, and immune dysregulation. Herein, we developed a hierarchical ROS-scavenging platform integrating nanoscale calcium hydride (CaH₂) within a microneedle (MN) patch to disrupt this degenerative cascade. Upon dissolution in wound exudate, CaH₂ nanoparticles react with water to generate sustained release of hydrogen gas (H₂) and calcium ions (Ca

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Research summary

The paper claims that a hierarchical ROS-scavenging platform can disrupt the cycle of stem cell senescence and immune dysregulation in diabetic wounds. This research is relevant as it addresses the underlying mechanisms of oxidative stress and stem cell function, which are critical factors in the aging process and age-related tissue repair.

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