Kaempferol inhibits atherosclerotic plaque development via dual-targeting of p53-p21-p16 senescence pathway and Nrf2/HO-1/NQO1 antioxidant mechanism: Insights from combined in vivo and in vitro research.

Xinyi Cai, Yajie Zhang, Weina Zhu, Ning Gu

Nanjing Hospital of Chinese Medicine, affiliated with Nanjing University of Chinese Medicine, Nanjing, China.. Electronic address: [email protected]. · pubmed

Paper

Abstract

Atherosclerosis, a leading cause of cardiovascular disease, is driven by aging-related endothelial cell senescence, oxidative stress, and inflammation. Kaempferol, a dietary flavonoid, exerts potent antioxidant and anti-senescence effects on the vasculature.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Kaempferol inhibits atherosclerotic plaque development through targeting senescence and antioxidant mechanisms. The paper addresses mechanisms related to aging and vascular health, which are critical in the context of longevity research.

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