Extension of lifespan by epicatechin, halofuginone and mitoglitazone in male but not female genetically heterogeneous mice.

Randy Strong, James F Nelson, Molly A Bogue, Jerry R Colca, Martin Denzel, Vivian Diaz, Brian N Finck, Vadim N Gladyshev, Steve Horvath, Nisi Jiang, Tracy Keller, Rolf F Kletzien, Ron Korstanje, Navasuja Kumar, Christiaan Leeuwenburgh, Elizabeth Fernandez, Andrzej Galecki, Brett Ginsburg, Melissa Han, Catherine Kaczorowski, Scott Leiser, Marisa Lopez-Cruzan, Ken Raj, Peter C Reifsnyder, Nadia A Rosenthal, Susanna Rosi, Anastasia Shindyapina, Peter Stacpoole, Adam B Salmon, Alexander Tyshkovskiy, Peter Walter, Malcolm Whitman, Richard A Miller, David E Harrison

Geriatric Research, Education and Clinical Center and Research Service, Department of Pharmacology, Barshop Institute for Longevity and Aging Studies, South Texas Veterans Health Care System, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.Geriatric Research, Education and Clinical Center and Research Service, Department of Pharmacology, Barshop Institute for Longevity and Aging Studies, South Texas Veterans Health Care System, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA. · pubmed

Paper

Abstract

Mice bred in 2021 were tested by the Interventions Testing Program (ITP) for possible lifespan benefits of 2BAct (2BA), dichloroacetate (DCA), Epicatechin (EPI), Forskolin (FSK), Halofuginone (HAL) and Mitoglitazone (MIT). All agents were administered in the diet ad libitum beginning at 7 months of age. In male mice, EPI increased median lifespan by ~ 5%, and HAL and MIT each increased median lifespan by ~ 9%. EPI and HAL, but not MIT, increased 90% survival. In addition to adding 3 new agents to the list of interventions identified by the ITP that extend lifespan, this report continues the strong male bias in the efficacy of life-extending drugs identified so far.

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Research summary

The paper claims that epicatechin, halofuginone, and mitoglitazone extend lifespan in male genetically heterogeneous mice. The research is relevant as it investigates potential interventions that directly affect lifespan extension, contributing to the understanding of aging mechanisms.

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