Elucidation of the potential molecular mechanisms of Buyang Huanwu Decoction in delaying cardiac aging: Based on network pharmacology, bioinformatics, and in vivo/in vitro experimental validation.

Xiaodong Duan, Yongan Deng, Minghao Feng, Chengkai Chen, Simin Yang, Shuting Zeng, Xiaodie Chen, Nan Xiao, Xiangyu Chen, Jianhua Li, Yixuan Huang, Yutong Yang, Min Yu, Guangwei Wang, Wenrong Yu, Li Zhang, Yi Wang, Zunpeng Shu

School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, 510006, PR China; Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Department of Biology, Faculty of Arts and Sciences, Beijing Normal University, Zhuhai, 519087, PR China.School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou, 510006, PR China; Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Department of Biology, Faculty of Arts and Sciences, Beijing Normal University, Zhuhai, 519087, PR China. · pubmed

Paper

Abstract

Cardiac aging is closely associated with the occurrence and progression of various cardiovascular diseases (CVD). Buyang Huanwu Decoction (BYHWD), a classical traditional Chinese medicine formula, is widely used clinically for cerebrovascular and cardiovascular diseases. However, its role in delaying cardiac aging and the underlying molecular mechanisms remain unclear.

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Research summary

The paper claims that Buyang Huanwu Decoction may delay cardiac aging through specific molecular mechanisms. The research addresses a potential intervention in the aging process of the heart, which is directly related to longevity and age-related diseases.

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