Molecular mechanisms of proliferative senescence and genomic instability in Werner syndrome and the WRN gene network.
Abstract
Ageing is a general, intrinsic and progressively deleterious process that affects all cells, tissues and organs albeit at different extent and rate in each individual. The complexity and universality of its phenotypic manifestations suggest a multifactorial origin. The autosomal recessive disorder Werner syndrome likely represents a segmental progeroid disorder since patients show several, but not all phenotypes of premature ageing.
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Research summary
The paper investigates the molecular mechanisms underlying proliferative senescence and genomic instability in Werner syndrome, linking it to aging processes. This research is relevant as it explores the biological underpinnings of a progeroid syndrome, potentially offering insights into the root causes of aging and age-related diseases.
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