Genome-wide association study meta-analysis uncovers novel genetic variants associated with olfactory dysfunction.

Mohammed Aslam Imtiaz, Konstantinos Melas, Adrienne Tin, Valentina Talevi, Honglei Chen, Myriam Fornage, Srishti Shrestha, Martin Gögele, David Emmert, Cristian Pattaro, Peter Pramstaller, Franz Förster, Katrin Horn, Thomas H Mosley, Christian Fuchsberger, Markus Scholz, Monique M B Breteler, N Ahmad Aziz

Population Health Sciences, German Centre for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, Bonn, 53127, Germany. · pubmed

Paper

Abstract

Olfactory dysfunction is among the earliest signs of many age-related neurodegenerative diseases and has been associated with increased mortality in older adults; however, its genetic basis remains largely unknown. Therefore, here we aimed to elucidate its genetic architecture through a genome-wide association study meta-analysis (GWMA).

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Research summary

The paper identifies novel genetic variants associated with olfactory dysfunction. This research is relevant as olfactory dysfunction is an early indicator of neurodegenerative diseases, which are closely linked to aging and longevity.

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