Inflammation Affects the Osteogenic Differentiation of Aged Periodontal Ligament Cells via NF-κB/FOXO3a/c-JUN Signalling.

Luying Zhu, Zhongyuan Tang, Renjie Hu, Yaxin Li, Xuan Li, Min Gu, Yanqi Yang

Faculty of Dentistry, The University of Hong Kong, Hong Kong, China.Faculty of Dentistry, The University of Hong Kong, Hong Kong, China. · pubmed

Paper

Abstract

This study aims to investigate the effect of inflammation on the senescence phenotype and osteogenic capacity of aged periodontal ligament cells (PDLCs), and to explore the regulatory role of the NF-κB signalling pathway in the osteogenesis of aged PDLCs.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Inflammation negatively impacts the osteogenic differentiation of aged periodontal ligament cells through the NF-κB signalling pathway. This study addresses the cellular mechanisms involved in aging and inflammation, which are relevant to understanding the biological processes that contribute to age-related decline.

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