High-Calorie Diet During Pregnancy Leads to Muscular Fibrosis and Neuromuscular Damage in Offspring Mice.

Jun Seok Son, Song Ah Chae, Yoon Ha Chun, Hongyang Wang, Zhihua Jiang, Min Du

Nutrigenomics and Exercise Biology Laboratory, Department of Obstetrics, Gynecology & Reproductive Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA. · pubmed

Paper

Abstract

Sarcopenia, recognized as an age-related loss of muscle mass and function, is a critical risk for geriatric health. We previously demonstrated that maternal high-fat diet (HFD) suppresses mitochondrial biogenesis during fetal skeletal muscle development, but the longitudinal effect of maternal HFD challenge on offspring muscle sarcopenia and fitness impairment remains unclear. Mitochondrial polymerase γ (PolG) mutation accelerates mitochondrial DNA mutations and leads to premature aging.

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Research summary

Maternal high-calorie diet during pregnancy leads to muscular fibrosis and neuromuscular damage in offspring mice. This study is relevant as it explores the long-term effects of maternal nutrition on offspring muscle health, which could contribute to understanding the mechanisms of aging and sarcopenia.

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