Nicotinamide phosphoribosyltransferase (Nampt) in Lateral Hypothalamus Maintains Skeletal Muscle Functions Through Lactate-Mediated Calcium Signalling in Male Mice.
Abstract
Sarcopenia has become an urgent socioeconomic problem in rapidly aging societies. The pathogenesis of age-associated sarcopenia is not fully understood and no effective therapeutic strategies have been developed to date. Recent studies have suggested the importance of the functional linkage between the brain and skeletal muscles in the pathogenesis of sarcopenia. However, the functional connections between the brain and skeletal muscles, particularly between the hypothalamus and skeletal muscles, remain unclear. In this study, we focused on the importance of nicotinamide adenine dinucleotide (NAD
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Research summary
The paper claims that nicotinamide phosphoribosyltransferase (Nampt) in the lateral hypothalamus plays a crucial role in maintaining skeletal muscle functions through lactate-mediated calcium signaling. This research is relevant as it explores the underlying mechanisms of sarcopenia, a significant age-related condition, and its connection to brain function, potentially addressing root causes of aging-related muscle decline.
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