Epigenetics in intestinal stem cells: Molecular mechanisms underpinning the guardians of homeostasis in health and aging-related senescence.
Abstract
The intestine is a vital organ of the digestive system, with its function largely reliant on the continuous regeneration of mucosal epithelial cells by healthy intestinal stem cells (ISCs). However, as we age, the regenerative potential of ISCs declines, primarily due to deleterious aging processes, such as cellular senescence, which contribute to the development of various chronic gut diseases. A growing body of evidence indicates that both healthy ISCs, which maintain intestinal homeostasis, and aging-associated senescent ISCs are profoundly influenced by epigenetic mechanisms. At the molecular level, dynamic and often reversible epigenetic modifications including chromatin remodeling, histone modifications, DNA methylation, N6-methyladenosine (m
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Research summary
The paper claims that epigenetic mechanisms significantly influence the regenerative potential of intestinal stem cells in the context of aging. This research is relevant as it addresses the underlying molecular mechanisms that contribute to the decline in stem cell function with age, which is a critical aspect of aging and longevity.
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