Exploring glycobiomarkers beyond senescence-associated β-galactosidase for studying aging in vitro.

Lucia Račková, Rebeka Kodríková, Marek Nemčovič, Erika Csekes, Zuzana Pakanová

Institute of Chemistry, Slovak Academy of Sciences, Dúbravská cesta 9, Bratislava, 845 38, Slovakia; Centre of Experimental Medicine, Slovak Academy of Sciences, Institute of Experimental Pharmacology and Toxicology, Dúbravská cesta 9, Bratislava, 841 04, Slovakia. Electronic address: [email protected] of Chemistry, Slovak Academy of Sciences, Dúbravská cesta 9, Bratislava, 845 38, Slovakia; Centre of Experimental Medicine, Slovak Academy of Sciences, Institute of Experimental Pharmacology and Toxicology, Dúbravská cesta 9, Bratislava, 841 04, Slovakia. Electronic address: [email protected]. · pubmed

Paper

Abstract

Cellular senescence, a phenomenon believed to contribute significantly to aging and age-related diseases, can be readily achieved under cell culture conditions. Alterations in the N-glycosylation of human blood glycoproteins have emerged as promising biomarkers of aging. However, knowledge about the in vitro use of glycobiomarkers for assessing cellular senescence remains limited. Our study utilized MALDI-TOF mass spectrometry to compare the alterations in the N-glycome of replicatively senescent human dermal fibroblasts and glyoxal- and H

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Research summary

The paper claims that alterations in the N-glycome of replicatively senescent human dermal fibroblasts can serve as glycobiomarkers for studying aging in vitro. This research is relevant as it explores potential biomarkers that could help in understanding the mechanisms of aging and cellular senescence, which are central to longevity research.

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