YY1-VDR axis-mediated autophagy slows the progression of intervertebral disc degeneration.

Piji Chen, Jianfeng Huang, Zhe Shen

Department of Clinical Laboratory, Yantian People's Hospital of Southern University of Science and Technology, Shenzhen, Guangdong 518083, PR China. Electronic address: [email protected]. · pubmed

Paper

Abstract

Aging is accompanied by degeneration of the intervertebral discs (IVDD), which leads to a poor quality of life and a significant socioeconomic burden. The present study aimed to explore the effect of transcription factor Yin and Yang 1 (YY1) on IVDD and to elucidate the potential underlying mechanism.

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Research summary

The study claims that the YY1-VDR axis mediates autophagy to slow the progression of intervertebral disc degeneration. This research is relevant as it explores a potential mechanism that could address the underlying biological processes associated with aging and age-related degeneration.

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