Vascular aging impairs active modulation of murine aortic stiffness by smooth muscle cells.

Koen W F van der Laan, Cédric H G Neutel, Margarita G Pencheva, Callan D Wesley, Dustin N Krüger, Casper G Schalkwijk, Guido R Y De Meyer, Wim Martinet, Koen D Reesink, Tammo Delhaas, Alessandro Giudici, Pieter-Jan Guns, Bart Spronck

Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands. · pubmed

Paper

Abstract

Aging causes changes to arterial contractility and tissue microstructure, resulting in arterial stiffening, a strong risk factor for cardiovascular diseases. Because the interaction between these effects is largely unexplored, this study aims to investigate how aging-induced changes in contractility and wall constituent microstructure impact arterial biomechanics in murine aortas. Vasoreactive responses of thoracic descending aortas of adult (5-mo-old,

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Research summary

The study investigates how aging-induced changes in arterial contractility and microstructure affect arterial stiffness. This research is relevant as it addresses the underlying mechanisms of vascular aging, which is a significant factor in age-related diseases and longevity.

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