Biomarkers of ageing of humans and non-human primates.

Zeming Wu, Jing Qu, Weiqi Zhang, Guang-Hui Liu

State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. · pubmed

Paper

Abstract

Ageing is characterized by progressive functional decline and increase in disease risk and imposes substantial burdens on human health. Identifying aging biomarkers in primates is crucial for advancing our understanding of human ageing and for informing interventions to mitigate age-related pathologies. However, a comprehensive grasp of these biomarkers is still lacking, hindering the translation of fundamental research into clinical practice. In this Review, we present the current knowledge on biomarkers of ageing at the cellular, tissue and organism levels in humans and non-human primates. Through systematic analysis of representative biomarkers across diverse biological contexts and scales, we discuss both the variability and the conservation of ageing-associated physiological changes, underscoring their importance in assessing and intervening in the ageing process. Finally, we critically assess challenges in ageing research and outline strategic avenues for future investigation.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper discusses the identification and analysis of biomarkers of ageing in humans and non-human primates. This research is relevant as it aims to enhance understanding of the ageing process and inform interventions that could mitigate age-related pathologies, addressing the root causes of ageing rather than merely treating symptoms.

Author of this paper? Send a correction.