Klotho attenuates D-galactose-induced cardiac aging through the ROS/NLRP3/pyroptosis pathway.

Sui-Sui Wang, Xu Zhang, Ze-Zhi Ke, Yu-Xin Zeng, Xiu-Yun Wen, Wen-Bin Liu, Jie Zhao, Xiao-Dong Zhuang, Li-Zhen Liao

Department of Cardiology, First School of Clinical Medicine, The First Affiliated Hospital of Guangdong Pharmaceutical University, 19 Nonglinxia Road, Yuexiu District, Guangzhou 510080, PR China; Department of Nuclear Medicine, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, No.466 Road Xingang, Guangzhou, Guangdong 510317, PR China. · pubmed

Paper

Abstract

Activation of NLRP3 inflammasome contributes to cardiac aging progression. Klotho, a recognised anti-aging protein, exerts protective effects against cardiac aging. In this study, we aimed to elucidate the protective effects of Klotho on D-galactose (D-gal)-induced cardiac aging and the underlying mechanisms.

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Research summary

Klotho protects against cardiac aging induced by D-galactose through the ROS/NLRP3/pyroptosis pathway. The study addresses mechanisms related to aging and the potential for Klotho to mitigate age-related cardiac decline, which is pertinent to longevity research.

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