A sequence-activated near-infrared fluorescence probe for precisely tracking

Jiahuan Nong, Pengcheng Li, Mingming Zhu, Yifeng Li, Changsheng Wang, Yutao Zhang, Chenxu Yan, Zhiqian Guo

Shanghai Key Laboratory of Functional Materials Chemistry, Institute of Fine Chemicals, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology Shanghai 200237 China [email protected] Key Laboratory of Functional Materials Chemistry, Institute of Fine Chemicals, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology Shanghai 200237 China [email protected]. · pubmed

Paper

Abstract

Real-time monitoring of senescent cells is of great significance for understanding and intervening in aging. Since overexpression of endogenous β-galactosidase (β-gal) is not unique to senescent cells, probes relying solely on β-gal activity could yield inaccurate senescent cell detection. Herein, we designed a dual-mode sequential response AND logic NIR probe MFB-βgal, which contains a β-gal-cleavable unit and a morpholine unit, serving as an enzymatic activity trigger and a lysosomal targeting moiety, respectively. MFB-OH is generated

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Research summary

The paper presents a novel dual-mode probe for tracking senescent cells, which is crucial for understanding the mechanisms of aging. The focus on accurately monitoring senescent cells addresses a fundamental aspect of aging research, potentially aiding in interventions that target the root causes of aging.

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