Parkin Acetylation-Mediated Mitophagy Orchestrates Periodontal Ligament Stem Cell Osteogenesis and Bone Regeneration During Ageing.

Kehan Zhang, Xiangyao Wang, Yuxiao Zhang, Yuanyuan Li, Yaxin Wu, Gaoshaer Nuerlan, Qilin Li, Jing Mao, Shiqiang Gong, Yan Liu

Center of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.Center of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. · pubmed

Paper

Abstract

To investigate the functional significance of mitophagy in age-related osteogenic decline and the underlying mechanisms using in vivo and in vitro models.

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Research summary

The paper claims that Parkin acetylation-mediated mitophagy plays a crucial role in osteogenesis and bone regeneration during aging. This research addresses mechanisms related to age-related decline in osteogenesis, which is pertinent to understanding and potentially mitigating aspects of aging.

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