Association Between Pulse Pressure and Structural Brain Changes in Aging: A Systematic Review and Meta-Analysis of Cross-Sectional and Longitudinal Studies.

Marina Cecelja, Ryan McNally, Jon Cleary, Phil Chowienczyk

School of Life Course and Population Sciences, Department of Twin Research and Genetic Epidemiology King's College London London United Kingdom.School of Life Course and Population Sciences, Department of Twin Research and Genetic Epidemiology King's College London London United Kingdom. · pubmed

Paper

Abstract

The aim of this study was to investigate the associations between pulse pressure (PP) and age-related structural brain changes including brain volumes, white matter hyperintensities (WMH), fractional anisotropy, silent brain lesions, microbleeds, cerebral blood flow and metabolism, and beta-amyloid accumulation.

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Research summary

The paper claims that there is an association between pulse pressure and various structural brain changes associated with aging. This study is relevant as it explores the relationship between cardiovascular health and brain aging, which may contribute to understanding the mechanisms underlying age-related cognitive decline.

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