Mitochondrial diagnostics reveal diffuse impairments in skeletal muscle energetics in aging mice.

Keon D Wimberly, Mia Y Kawaida, Abigail L Tice, Xiaoping Luo, Jacob A Lackey, Samuel Alvarez, Lan Wei-LaPierre, Russell T Hepple, Terence E Ryan

Department of Applied Physiology and Kinesiology, The University of Florida, Gainesville, FL, USA. · pubmed

Paper

Abstract

Aging is associated with progressive declines in skeletal muscle mass, strength, and endurance, often linked to mitochondrial dysfunction. However, a complete understanding of mitochondrial impairments during aging is lacking. Herein, we examined how biological sex and aging affect muscle function and mitochondrial energy transduction.

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Research summary

The paper claims that aging and biological sex affect muscle function and mitochondrial energy transduction in skeletal muscle. This research is relevant as it investigates mitochondrial dysfunction, a potential root cause of aging-related decline in muscle function, which is crucial for understanding and potentially mitigating age-related deterioration.

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