Effects of aging and anti-aging dietary restriction on regulators of the [NADPH]/[NADP

Leah E Jamerson, Patrick C Bradshaw

Department of Biomedical Sciences, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, 37614, United States. Electronic address: [email protected] of Biomedical Sciences, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN, 37614, United States. Electronic address: [email protected]. · pubmed

Paper

Abstract

Dietary restriction (DR), which slows aging, increases the ratio of reduced glutathione (GSH) to oxidized glutathione disulfide (GSSG) in the brain. DR increases liver cytoplasmic [NADPH]/[NADP

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Dietary restriction enhances the ratio of reduced to oxidized glutathione in the brain, which may contribute to longevity. The study investigates mechanisms related to aging and dietary interventions that could potentially influence lifespan and age-related health.

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