Single-cell transcriptomic and genomic changes in the ageing human brain.

Ailsa M Jeffries, Tianxiong Yu, Jennifer S Ziegenfuss, Allie K Tolles, Christina E Baer, Cesar Bautista Sotelo, Yerin Kim, Zhiping Weng, Michael A Lodato

Department of Molecular, Cell and Cancer Biology, Genome Integrity Program, University of Massachusetts Chan Medical School, Worcester, MA, USA.Department of Molecular, Cell and Cancer Biology, Genome Integrity Program, University of Massachusetts Chan Medical School, Worcester, MA, USA. · pubmed

Paper

Abstract

Over time, cells in the brain and in the body accumulate damage, which contributes to the ageing process

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates single-cell transcriptomic and genomic changes in the ageing human brain. This research is relevant as it explores the biological mechanisms underlying aging, which could contribute to understanding and potentially addressing the root causes of age-related decline.

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