Metabolomic-based aging clocks.

A Ibáñez de Opakua, R Conde, A de Diego, M Bizkarguenaga, N Embade, S C Lu, J M Mato, O Millet

ATLAS Molecular Pharma, Parque Tecnológico de Bizkaia, Ed. 800, 48160, Derio, Spain.ATLAS Molecular Pharma, Parque Tecnológico de Bizkaia, Ed. 800, 48160, Derio, Spain. · pubmed

Paper

Abstract

Molecular aging clocks estimate biological age from molecular biomarkers and often outperform chronological age in predicting health outcomes. Types include epigenetic, transcriptomic, proteomic, and metabolomic clocks. NMR-based metabolomic clocks provide a non-invasive, high-throughput platform to assess metabolic health. We summarize key NMR-based models and present a new approach that combines high predictive accuracy with clinical interpretability, identifying disease-specific metabolic distortions and supporting risk stratification and early detection of accelerated aging.

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Research summary

The paper presents a novel NMR-based metabolomic approach for estimating biological age and identifying metabolic distortions related to aging. This research is relevant as it aims to improve the understanding of biological aging processes and offers potential for early detection and risk stratification, which are crucial for addressing the root causes of aging.

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