Sulfated Fucooligosaccharides Ameliorated Neuroinflammation in D-Galactose-Induced Aging Model Mice via the Gut-Brain Axis.

Meilan Xue, Xuehan Zhang, Yifan Zhou, Jiayi Yan, Haiqi Gao, Yixian Bai, Jing Shi, Yuhan Liu, Yan Xu, Nan Zhang, Lu Li, Shaobo Shi, Hui Liang

School of Basic Medicine, Qingdao University, 308 Ningxia Road, Qingdao 266071, PR China. · pubmed

Paper

Abstract

This study was aimed to reveal the neuroprotective effect of sulfated fucooligosaccharides (FOS) in an aging mouse model induced by d-galactose. The results showed that FOS treatment ameliorated inflammation, improved behavioral decline in memory and cognition, and exerted neuroprotective effects. FOS reduced microglia activation by decreasing the expression of P38 mitogen-activated protein kinase (P38 MAPK), cyclic-AMP response binding protein (CREB), cyclooxygenase-2 (COX-2), and prostaglandin E2 (PGE2). In addition, FOS improved intestinal mucosal barrier damage and reduced the release of lipopolysaccharide. FOS increased the diversity of the gut flora and promoted a significant enrichment of the

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Research summary

Sulfated fucooligosaccharides (FOS) ameliorate neuroinflammation and cognitive decline in an aging mouse model. The study addresses neuroinflammation, which is a significant factor in the aging process, and explores a potential intervention that could impact age-related cognitive decline.

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