Partial Reprogramming in Senescent Schwann Cells Enhances Peripheral Nerve Regeneration via Restoration of Stress Granule Homeostasis.

Peilin Wang, Renyuan Wang, Yilin Huo, Ying Peng, Chuanliang Fu, Yi Hu, Zun Ren, Yersen Mulat, Hao Zhang, Dongsheng Jiang, Haodong Lin

Trauma Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China.Trauma Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China. · pubmed

Paper

Abstract

Partial reprogramming (pulsed expression of reprogramming transcription factors) ameliorates multiple tissue functions in aged mice; however, its impact on peripheral nerve regeneration remains largely unexplored. In this study, the temporal dynamics of Schwann cells following sciatic nerve injury in young and aged rats are systematically examined using single-cell transcriptomics to identify a Runx2

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Research summary

Partial reprogramming of Schwann cells enhances peripheral nerve regeneration by restoring stress granule homeostasis. This research addresses mechanisms related to cellular aging and regeneration, which are crucial for understanding and potentially mitigating age-related decline in tissue function.

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