A single-cell transcriptome atlas of pig skin reveals cellular heterogeneity from embryonic development to postnatal aging.

Ting Zheng, Rong Yuan, Yu Zhang, Qin Zou, Yifei Wang, Yujing Li, Zhengyin Gong, Zhengli Chen, Yanzhi Jiang

Department of Zoology, College of Life Science, Sichuan Agricultural University, Ya'an, Sichuan, 625014, China.Department of Zoology, College of Life Science, Sichuan Agricultural University, Ya'an, Sichuan, 625014, China. · pubmed

Paper

Abstract

Mammalian skin exhibits profound cellular and molecular restructuring across lifespan, yet an integrated single-cell mapping from embryogenesis to senescence remains limited. The Chenghua (CH) pig, with exceptional skin thickness characteristics, provides a promising model for investigating human skin development and physiology.

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Research summary

The paper presents a single-cell transcriptome atlas of pig skin that maps cellular changes from embryonic development to postnatal aging. This research is relevant as it explores cellular and molecular changes associated with aging, which could provide insights into the mechanisms of skin aging and potential interventions.

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