BMP10 attenuates age-related atrial fibrillation susceptibility through improving mitochondrial function in atrial cardiomyocytes.

Qiang Gao, Yukai Cao, Xinbo Zhao, Hongyuan Mu, Yue Li, Yue Yuan

Department of Cardiology, The First Affiliated Hospital, Harbin Medical University, Harbin, 150001, China; Department of General Medicine, The First Affiliated Hospital, Harbin Medical University, Harbin, 150001, China.Department of Cardiology, The First Affiliated Hospital, Harbin Medical University, Harbin, 150001, China; Department of General Medicine, The First Affiliated Hospital, Harbin Medical University, Harbin, 150001, China. · pubmed

Paper

Abstract

Although emerging clinical studies exhibit a strong association of circulating bone morphogenetic protein (BMP10) level with adverse outcomes in patients with atrial fibrillation (AF), also in older individuals. The exact role of BMP10 in age-related AF pathogenesis and potential mechanisms remain unknown.

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Research summary

BMP10 improves mitochondrial function in atrial cardiomyocytes, potentially reducing age-related atrial fibrillation susceptibility. The study addresses a mechanism related to aging and cardiovascular health, which is pertinent to longevity research.

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