Colchicine and Longitudinal Dynamics of Clonal Hematopoiesis: An Exploratory Substudy of the LoDoCo2 Trial.

Niekbachsh Mohammadnia, Liying Xue, Lucas T W Vestjens, Md Mesbah Uddin, Abhishek Niroula, Dominique P V de Kleijn, Arend Mosterd, Aernoud T L Fiolet, Tetsushi Nakao, John W Eikelboom, Aysun Cetinyurek-Yavuz, Gina M Peloso, Willem A Bax, Niels P Riksen, Pradeep Natarajan, Jan H Cornel, Saloua El Messaoudi, Michael C Honigberg

Department of Cardiology, Radboud University Medical Center, Nijmegen, the Netherlands.Department of Cardiology, Radboud University Medical Center, Nijmegen, the Netherlands. · pubmed

Paper

Abstract

Clonal hematopoiesis (CH) is an aging-related hematologic condition associated with increased risk for cardiovascular events. Larger CH clones associate more strongly with cardiovascular risk. Preclinical data indicate that inflammatory signaling drives expansion of CH clones and CH-associated cardiovascular disease. However, the effect of anti-inflammatory therapies on CH clonal dynamics in humans is unclear.

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Research summary

The paper investigates the effects of colchicine, an anti-inflammatory therapy, on the dynamics of clonal hematopoiesis, which is associated with aging and cardiovascular risk. This research is relevant as it explores potential interventions that could address underlying mechanisms of aging-related conditions.

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