Neurometabolomic impacts of wood smoke and protective benefits of anti-aging therapeutics in aged female C57BL/6J mice.

David Scieszka, Jonathan Hulse, Haiwei Gu, Amanda Barkley-Levenson, Ed Barr, Marcus Garcia, Jessica G Begay, Guy Herbert, Mark McCormick, Jonathan Brigman, Andrew Ottens, Barry Bleske, Kiran Bhaskar, Matthew J Campen

Department of Pharmaceutical Sciences, 1 University of New Mexico College of Pharmacy, MSC09 5360, Albuquerque, NM, 87131-0001, USA.Department of Pharmaceutical Sciences, 1 University of New Mexico College of Pharmacy, MSC09 5360, Albuquerque, NM, 87131-0001, USA. · pubmed

Paper

Abstract

Wildland fires in the United States have increased in frequency and scale over the past 30 years exposing millions of people to hazardous air pollutants. Among others, aging individuals are particularly vulnerable to the effects of wildfire smoke. In this study, we assessed the neurobiological impacts of wood smoke (WS) on aged mice and the potential of anti-aging therapeutics to mitigate these impacts.

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Research summary

The study investigates the neurobiological impacts of wood smoke on aged mice and explores the potential of anti-aging therapeutics to mitigate these effects. This research is relevant as it addresses the neurobiological consequences of environmental factors on aging and the potential for therapeutic interventions aimed at improving healthspan.

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