Failure of efficient cardiac proteostatic adaptations to chronic cAMP-stress is associated with accelerated heart aging.

Maria Grazia Perino, Miguel Calvo-Rubio Barrera, Daniel R Riordon, Giulio Agnetti, Alexander Maltsev, Admira Parveen, Christopher H Morrell, Ismayil Ahmet, Khalid Chakir, Yelena S Tarasova, Jia-Hua Qu, Kirill V Tarasov, Alexey E Lyashkov, Yevgeniya O Lukyanenko, Hikmet Kadioglu, Mark Ranek, Rafael De Cabo, Edward G Lakatta

Laboratory of Cardiovascular Science, Intramural Research Program, National Institute On Aging, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD, 21224, USA. [email protected] of Cardiovascular Science, Intramural Research Program, National Institute On Aging, National Institutes of Health, 251 Bayview Blvd, Baltimore, MD, 21224, USA. [email protected]. · pubmed

Paper

Abstract

Dysregulated proteostasis is a hallmark of aging. We investigated how efficiently proteostatic adaptations to chronic cardiac cyclic-adenosine-monophosphate (cAMP)-dependent stress change with aging in mice harboring marked cardiac-specific over-expression of adenylyl cyclase VIII (TG

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Research summary

The paper claims that the failure of cardiac proteostatic adaptations to chronic cAMP-stress accelerates heart aging. This research addresses the mechanisms of aging at the cellular level, specifically focusing on proteostasis in the context of heart aging, which is directly relevant to understanding and potentially mitigating age-related decline.

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