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RESEARCH PAPER / 2025-09-01

REV-ERBα regulates brain NAD

Jiyeon Lee, Ryeonghwa Kang, Sohui Park, Ibrahim O Saliu, Minsoo Son, Jaymie R Voorhees, Julie M Dimitry, Elsa I Quillin, Lauren N Woodie, Brian V Lananna, Li Gan, Young-Ah Goo, Guoyan Zhao, Mitchell A Lazar, Thomas P Burris, Erik S Musiek

Department of Neurology and Center On Biological Rhythms And Sleep, Washington University in St. Louis School of Medicine, St. Louis, MO, USA. [email protected] of Neurology and Center On Biological Rhythms And Sleep, Washington University in St. Louis School of Medicine, St. Louis, MO, USA. [email protected]. · pubmed

Abstract

Nicotinamide adenine dinucleotide (NAD

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

REV-ERBα regulates brain NAD levels. The regulation of NAD, a crucial coenzyme involved in cellular metabolism and energy production, is relevant to understanding mechanisms of aging and potential interventions for lifespan extension.

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