Spermidine reproduces the anti-inflammatory effects of intermittent fasting and prevents urate and calcium pyrophosphate crystal-induced inflammation.

Chinh Nghia Pham, Florence Castelli, Flora Finet, Charles Leroy, Céline Chollet, Twinu Wilson Chirayath, Subhalaxmi Moitra, Mylène Zarka, Agnès Ostertag, François Brial, Christèle Combes, Augustin Latourte, Thomas Bardin, François Fenaille, Pascal Richette, Hang Korng Ea

Université Paris Cité, Inserm U1132, BIOSCAR, Hôpital Lariboisière, Paris, France.Université Paris Cité, Inserm U1132, BIOSCAR, Hôpital Lariboisière, Paris, France. · pubmed

Paper

Abstract

Gout due to the formation of monosodium urate (MSU) crystals and calcium pyrophosphate (CPP) deposition disease are two major types of microcrystalline pathologies in adults. They are responsible for recurrent flares that rely on interleukin (IL)-1β via activation of the NLRP3 inflammasome. Intermittent fasting (IF) is a non-pharmacological intervention that improves age-related diseases and reduces inflammation.

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Research summary

Spermidine mimics the anti-inflammatory effects of intermittent fasting and mitigates inflammation caused by microcrystalline pathologies. The paper is relevant as it explores a potential intervention (spermidine) that may address inflammation, a key factor in age-related diseases, and connects it to the broader context of intermittent fasting, which is associated with longevity.

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