Deregulated miR-145 and miR-27b in hutchinson-gilford progeria syndrome: implications for adipogenesis.

Felix Quirin Fenzl, Eva-Maria Lederer, Louisa Brumma, Peter Krüger, Moritz Schroll, Frederic Wilming, Karima Djabali

Epigenetics of Aging, Department of Dermatology and Allergy, TUM School of Medicine, Munich Institute of Biomedical Engineering (MIBE), Technical University of Munich (TUM), Garching 85748, Germany.Epigenetics of Aging, Department of Dermatology and Allergy, TUM School of Medicine, Munich Institute of Biomedical Engineering (MIBE), Technical University of Munich (TUM), Garching 85748, Germany. · pubmed

Paper

Abstract

Hutchinson-Gilford progeria syndrome (HGPS) is a rare and fatal disorder that causes premature aging, affecting approximately one in 4-8 million births. Most cases result from a mutation in the lamin A/C (

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the role of deregulated miR-145 and miR-27b in Hutchinson-Gilford progeria syndrome, suggesting implications for adipogenesis. The focus on a rare aging-related disorder and its molecular mechanisms provides insights into the biological processes of aging, making it relevant to longevity research.

Author of this paper? Send a correction.