How to measure and model cardiovascular aging.

Luke Spray, Gavin Richardson, Laura K Booth, Judith Haendeler, Joachim Altschmied, Daniel I Bromage, Sienna B Wallis, Konstantinos Stellos, Simon Tual-Chalot, Ioakim Spyridopoulos

Translational and Clinical Research Institute, Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Newcastle University, Centre for Life, Newcastle Upon Tyne NE1 3BZ, UK.Translational and Clinical Research Institute, Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Newcastle University, Centre for Life, Newcastle Upon Tyne NE1 3BZ, UK. · pubmed

Paper

Abstract

Most acquired cardiovascular diseases are more common in older people, and the biological mechanisms and manifestations of aging provide insight into cardiovascular pathophysiology. Measuring aging within the cardiovascular system may help to better understand risk profiles for specific individuals and direct targeted preventative therapy. In this review, we explore telomere attrition, cellular senescence, epigenetic modifications, and mitochondrial dysfunction as key molecular mechanisms of aging. These phenomena are associated with cardiovascular disease through endothelial dysfunction and systemic inflammation, which are measurable in clinical practice with a variety of clinical, laboratory, and imaging techniques. Finally, we discuss that the next tools for modelling cardiovascular aging must be capable of incorporating a vast amount of diverse data from a given patient, pointing to recent developments in artificial intelligence and machine learning.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that measuring and modeling cardiovascular aging can enhance understanding of individual risk profiles and direct targeted preventative therapy. This research is relevant as it addresses the biological mechanisms of aging that contribute to cardiovascular diseases, aiming to improve preventative strategies rather than merely treating symptoms.

Author of this paper? Send a correction.