The heart-brain crosstalk in age related cardiovascular and neurodegenerative diseases.

Muhammad Ahmad Fahim, Yao Yao, Srinivas M Tipparaju, Wanling Xuan

Department of Pharmaceutical Sciences, USF Health Taneja College of Pharmacy, University of South Florida, Tampa, FL, 33612, USA.Department of Pharmaceutical Sciences, USF Health Taneja College of Pharmacy, University of South Florida, Tampa, FL, 33612, USA. · pubmed

Paper

Abstract

Aging is a major risk factor for both cardiovascular and neurodegenerative diseases. The bidirectional communication between the heart and brain, commonly referred to as heart-brain crosstalk, is increasingly disrupted with age. In this review, we summarize current evidence linking cardiovascular and neurodegenerative disorders, particularly in the context of aging. We also discuss the underlying mechanisms responsible for the heart-brain crosstalk, including blood-brain barrier breakdown, vascular dysfunction, nervous system alterations, inflammation, and endocrine dysregulation, which may explain the frequent co-occurrence of dysfunction in both organs during aging. Understanding these interconnections provides critical insights into the pathophysiology of age-related diseases and highlights potential therapeutic targets to preserve both heart and brain health in the aging population.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper discusses the mechanisms of heart-brain crosstalk and its implications for age-related diseases. This research is relevant as it explores the interconnectedness of cardiovascular and neurodegenerative disorders in the context of aging, which could inform strategies for addressing the root causes of age-related health decline.

Author of this paper? Send a correction.