Integrative analysis of inhibition of advanced glycation end-products accumulation and prevention of aging muscle deterioration in animals and human models.

Moon Jin Lee, Jin-Ho Park, Seong-Min Hong, Sun Yeou Kim, Jiyoun Kim

Department of Physical Education, College of Education, Korea University, Seoul 02841, Republic of Korea; Department of Exercise Rehabilitation, Institute of Human Convergence Health Science, Gachon University, Incheon, Republic of Korea.Department of Physical Education, College of Education, Korea University, Seoul 02841, Republic of Korea; Department of Exercise Rehabilitation, Institute of Human Convergence Health Science, Gachon University, Incheon, Republic of Korea. · pubmed

Paper

Abstract

Advanced glycation end-products (AGEs) contribute to metabolic dysfunction and sarcopenia by promoting oxidative stress and inflammation. The therapeutic impact of exercise on AGEs-induced muscle deterioration and clinical relevance of skin autofluorescence (SAF) as a biomarker remain unclear. Therefore, we aimed to comprehensively investigate the physiological effects of AGEs using two complementary approaches.

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Research summary

The paper investigates the role of advanced glycation end-products in muscle deterioration and explores potential therapeutic interventions. This research is relevant as it addresses a root cause of aging-related muscle loss, contributing to the understanding of mechanisms underlying sarcopenia and metabolic dysfunction in aging.

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