Ageing-Dependent Thyroid Hormone Receptor α Reduction Activates IP3R1-Meditated Ca

Runqing Shi, Yusheng Zhang, Gong Chen, Jiru Zhang, Jing Liu, Hao Zhu, Minne Sun, Yu Duan

Department of Gerontology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, China.Department of Gerontology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, China. · pubmed

Paper

Abstract

Sarcopenia profoundly impacts the quality of life and longevity in elderly populations. Notably, alterations in thyroid hormone (TH) levels during ageing are intricately linked to the development of sarcopenia. In skeletal muscle, the primary action of TH is mediated through the thyroid hormone receptor alpha (TRα). Emerging evidence suggests that decreased TRα expression may precipitate mitochondrial dysfunction in ageing skeletal muscle tissues. Yet, the precise mechanisms and the potential causative role of TRα deficiency in sarcopenia are not fully understood. This study suggests that TRα may regulate mitochondrial calcium (Ca

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Research summary

The paper claims that reduced expression of thyroid hormone receptor alpha (TRα) activates mitochondrial dysfunction in skeletal muscle, contributing to sarcopenia in aging. This research is relevant as it explores a potential mechanistic link between thyroid hormone signaling and age-related muscle degeneration, which could inform strategies for addressing the root causes of aging-related decline in muscle function.

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