Lipid metabolism in age-related musculoskeletal disorders: insights into sarcopenia and osteoporosis.

Shivum Lal, Shreya Gunji, Pankaj Ahluwalia, Ravindra Kolhe, Wendy B Bollag, William D Hill, Meghan E McGee-Lawrence, Carlos M Isales, Sadanand Fulzele

Department of Medicine, Augusta University, Augusta, GA, USA.Department of Medicine, Augusta University, Augusta, GA, USA. · pubmed

Paper

Abstract

Musculoskeletal disorders (MSDs), notably sarcopenia and osteoporosis, profoundly affect aging individuals. This review explores lipid metabolism's role in age-related MSD pathophysiology, highlighting fatty acid uptake, lipid signaling, and lipotoxicity in muscle deterioration. It further addresses lipid-mediated regulation of osteoclasts, osteoblasts, and bone remodeling, emphasizing age-associated metabolic shifts exacerbating bone loss. Emerging therapeutic strategies targeting lipid pathways for MSD treatment are also discussed. This review integrates recent findings in muscle and bone lipid metabolism to deepen understanding of lipid dysregulation in musculoskeletal disorders and explore potential metabolic intervention strategies.

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Research summary

The paper claims that lipid metabolism plays a crucial role in the pathophysiology of age-related musculoskeletal disorders, suggesting potential therapeutic strategies targeting lipid pathways. This research is relevant as it addresses underlying metabolic mechanisms contributing to aging-related conditions, rather than merely treating symptoms.

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