Hydrogen promoted mitochondrial autophagy and alleviated CIH-induced vascular endothelial cell senescence by regulating oxidative stress.

Dongli Li, Qingqing Liu, Xintong Fan, Kerong Qi, Mengfan Sun, Jixian Song, Yajing Guo, Ensheng Ji

Hebei Technology Innovation Center of TCM Combined Hydrogen Medicine, Hebei University of Chinese Medicine, Shijiazhuang, China.Hebei Technology Innovation Center of TCM Combined Hydrogen Medicine, Hebei University of Chinese Medicine, Shijiazhuang, China. · pubmed

Paper

Abstract

Obstructive sleep apnea (OSA), characterized by recurrent upper airway collapse during sleep, has been linked to systemic physiological impairment and accelerated vascular senescence through chronic intermittent hypoxia (CIH). Currently, there is no approved medication to treat the complications of OSA. Molecular hydrogen (H

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Research summary

The paper claims that hydrogen promotes mitochondrial autophagy and alleviates vascular endothelial cell senescence induced by chronic intermittent hypoxia. The research addresses mechanisms related to oxidative stress and cellular senescence, which are fundamental aspects of aging and longevity.

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